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HIV Dementia
P-glycoprotein May Prevent Microglia Exposure To Therapeutic Drugs
November 19th, 2001
by Michael Greer, senior medical writer - P-glycoprotein appears to block HIV protease inhibitors from reaching viral targets in the brain, according to researchers in Canada. "In the central nervous system, the primary targets of the human immunodeficiency virus-1 (HIV-1) are microglia, resulting in a disorder called HIV-1 dementia," explained Gloria Lee and colleagues at the University of Toronto, the University of Montreal, and the Toronto Western Research Institute. "P-glycoprotein (P-gp), a membrane-associated ATP-dependent efflux transporter, limits entry into the brain of numerous xenobiotics, including anti-HIV drugs (i.e., protease inhibitors)." ...
Source: AIDS Weekly (2001-11-19)
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