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AIDS Weekly

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AIDS And HIV Vaccine



Viral Protein Alterations Have Similar Impact On HIV, SHIV Specific Antibodies



November 19th, 2001

by Michael Greer, senior medical writer - Researchers in New York City have presented evidence in favor of the controversial use of simian/human immunodeficiency virus (SHIV)-based models for HIV vaccine testing.

Susan E. Malenbaum and colleagues at the Rockefeller University's Aaron Diamond AIDS Research Center conducted a study comparing the human and macaque immune responses to HIV and SHIV strains with divergent envelope protein features.

Both human and macaque responses were similarly affected by changes in envelope glycoproteins, they said.

Malenbaum and coworkers evaluated the efficacy of antibodies in neutralizing isogenic...


Source: AIDS Weekly (2001-11-19)

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