Pathology

HIV Rides Into Cells On Membrane Rafts, NIAID Scientists Say

Published in AIDS Weekly, December 10th, 2001

The AIDS-causing virus, HIV, must attach to cholesterol-rich regions of a cell's membrane before it can do its destructive work, researchers at the National Institute of Allergy and Infectious Diseases (NIAID) have discovered.

When the investigators removed cholesterol from the cells, HIV lost much of its ability to produce new virus particles and infect additional cells. These findings provide a more detailed picture of how HIV travels into and out of cells as well as possible ways to block that travel.

"Our research raises the intriguing possibility that widely used cholesterol-lowering drugs might have an effect in humans similar to what we have...

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Source: AIDS Weekly (2001-12-10)

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