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AIDS and HIV Vaccine

DNA Prime With Sendai Virus Booster Effective

Published in AIDS Weekly, January 28th, 2002

by Michael Greer, senior medical writer - A Sendai virus-based HIV vaccine is effective when administered after a DNA prime, according to researchers in Japan.

"Heterologous prime/boost regimens are AIDS vaccine candidates because of their potential for inducing cellular immune responses," explained Tetsuro Matano and colleagues at the National Institute of Infectious Diseases' AIDS Research Center in Tokyo.

This strategy produced vigorous and persistent antiviral responses in animals, Matano and coauthors reported.

A cohort of rhesus macaques received a priming dose of env- and nef-deleted simian-human...

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