AIDS and HIV Therapy
DC-SIGN could be therapeutic target
Published in AIDS Weekly, June 24th, 2002
"Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) is a monocyte-derived dendritic cell (MDDC)-specific lectin which participates in dendritic cell (DC) migration and DC-T lymphocyte interactions at the initiation of immune responses and enhances trans-infection of T cells through its HIV gp120-binding ability," explained Dr. Miguel Relloso and colleagues at Gregorio Maranon General University Hospital in Madrid.
DC-SIGN expression relies on the activity of a few cytokines, whose...
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Source: AIDS Weekly (2002-06-24)
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