AIDS and HIV Pathogenesis
Viral Th2 cytokine expression can enhance infection
Published in AIDS Weekly, July 1st, 2002
Dr. Iouri L. Kozyrev and colleagues at Kyoto University and Kyoto Prefectural University of Medicine in Kyoto assessed the impact of interleukin (IL)-5 expression on the replication kinetics of highly pathogenic simian/human immunodeficiency virus (SHIV) in vivo.
A SHIV strain expressing IL-5 (NI-IL5) demonstrated enhanced replication ability in vivo, confirming earlier in vitro results, Kozyrev and coauthors found.
The researchers inoculated three rhesus macaques with high...
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Source: AIDS Weekly (2002-07-01)
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