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AIDS and HIV Therapy

Unsuccessful antiretroviral therapy can lead to brain damage

Published in AIDS Weekly, July 15th, 2002

by Michael Greer, senior medical writer - Unsuccessful antiretroviral therapy for HIV infection can trigger a severe neurological disorder, researchers in the United States warn.

T. Dianne Langford and colleagues at the University of California and the Veterans Affairs San Diego Health Care System in San Diego investigated "a severe form of demyelinating HIV-associated leukoencephalopathy in AIDS patients failing highly active antiretroviral therapy (HAART)."

Temporary HAART-induced immune recovery may have created conditions conducive to HIV brain infiltration and subsequent white matter degeneration, Langford and coauthors found.

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