HIV/AIDS Therapy

Liquid chromatography can be used to monitor levels of multiple antiretroviral drugs

Published in AIDS Weekly, August 19th, 2002

by Michael Greer, senior medical writer - Researchers in France say that they have developed a method to measure levels of up to eight antiretroviral HIV drugs in a single assay.

Karine Titier and colleagues at Pellegrin Hospital and Victor Segalen University in Bordeaux evaluated the performance of a high-performance liquid chromatographic (HPLC) technique for finding plasma concentrations of six HIV protease inhibitors and two nonnucleoside HIV reverse transcriptase inhibitors (NNRTIs).

This assay gave accurate and simultaneous quantitations for plasma levels of all eight antiretroviral agents, Titier and coauthors said.

The...

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Source: AIDS Weekly (2002-08-19)

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