Virology

Discovery may lead to new HIV drugs, say Jefferson scientists

Published in AIDS Weekly, September 2nd, 2002

When scientists at London's King's College and their colleagues elsewhere uncovered the identity of a gene that prevents HIV from reproducing, but which is itself blocked by an HIV protein, they took a huge step in solving one of the great puzzles of the virus' biology.

What's more, the discovery, said virologist Roger J. Pomerantz, MD, "could start a new genre of AIDS drugs."

Researchers found that a gene called CEM15 is a natural inhibitor of HIV, acting as a brake on HIV's development. They showed that biologically tying up a protein called Vif, or Virion infectivity factor, allows CEM15 to stop the virus from replicating.

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Source: AIDS Weekly (2002-09-02)

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