HIV/AIDS Therapy

Caveolin-1 can prevent viral protein expression

Published in AIDS Weekly, September 30th, 2002

by Michael Greer, senior medical writer - Researchers in the United States have identified a protein that could act as a novel treatment for HIV infection.

"Caveolin-1 (Cav-1) is a major protein constituent of caveolae, a type of plasma membrane raft," explained Manuel Llano and colleagues working at the Mayo Clinic in Rochester, Minnesota.

Cav-1 was able to selectively suppress the expression of key HIV proteins, Llano and coauthors found.

At low levels, Cav-1 prevented expression of HIV-1 and HIV-2 proteins, the researchers reported. Exposure to Cav-1 did not impair protein expression by other viruses and had no deleterious...

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Source: AIDS Weekly (2002-09-30)

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