AIDS Therapy

Study sheds light on cause of an AIDS treatment side effect

Published in AIDS Weekly, October 28th, 2002

Highly active antiretroviral therapy, or HAART, is the standard of care for HIV/AIDS patients and has prolonged the lives of countless persons with the disease.

HAART has been associated, however, with the emergence of lipodystrophy syndromes. In the September 2002 issue of the journal Mitochondrion, researchers from the National Cancer Institute (NCI), the National Institute of Standards and Technology (NIST), and Purdue University, West Lafayette, Ind., report that protease inhibitors, a component of HAART, can lead to mitochondrial toxicity. The effect, seen in this test tube study, of protease inhibitors on mitochondria could help explain the biology behind...

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Source: AIDS Weekly (2002-10-28)

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