HIV/AIDS Pathogenesis

Specific effector activity reduces infection risk

Published in AIDS Weekly, November 4th, 2002

by Michael Greer, senior medical writer - Researchers in Canada have confirmed that HIV-specific T-cell activity reduces the risk of infection after exposure to the virus.

George Makedonas and colleagues at McGill University in Montreal and the University of Montreal assessed the impact of HIV-specific cytotoxic T lymphocyte activity on HIV-exposed, uninfected (EU) patients' risk of seroconversion.

Virus-specific CD8+ effector cell responses were associated with a significantly reduced seroconversion risk for drug users sharing needles with infected partners, Makedonas and coauthors found.

The researchers examined cytotoxic...

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Source: AIDS Weekly (2002-11-04)

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