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HIV/AIDS Therapy

Antiretroviral therapy restores normal stem cell activity

Published in AIDS Weekly, November 4th, 2002

by Michael Greer, senior medical writer - Antiretroviral therapy against HIV infection can restore normal hematopoietic stem cell activity, researchers in Italy say.

"Haematological abnormalities frequently occur in patients infected by human immunodeficiency virus-type 1 (HIV-1)," according to Antonella Isgro and colleagues at the University of Rome "La Sapienza" and the San Raffaele Telethon Institute for Gene Therapy in Milan. "Increasing evidence indicates that bone marrow suppression (BM) results from viral infection of accessory cells, with impaired stromal function and alteration of haematopoietic growth factor network."

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