Published in AIDS Weekly, November 11th, 2002
"The transcription factor NF-kappaB plays a central role in the human immunodeficiency virus type 1 (HIV-1) activation pathway. HIV-1 transcription is also regulated by protein acetylation," explained Vincent Quivy and colleagues at the Free University of Brussels and other institutions in Belgium, France, and the Netherlands.
A pair of agents that inhibit protein deacetylation can be used to disrupt the HIV latency process, preventing the virus from retreating to cellular reservoirs,...
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