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HIV/AIDS Cancer

Interleukin-6 enhances human herpesvirus-8 activity

Published in AIDS Weekly, December 2nd, 2002

by Michael Greer, senior medical writer - The cytokine interleukin (IL)-6 may play a key role in the development of several AIDS-related malignancies, researchers in Japan say.

"Human herpesvirus-8 (HHV-8) is etiologically associated with Kaposi's sarcoma (KS), body cavity-based lymphoma (BCBL), and multicentric Castleman's disease (MCD)," according to Jian Song and colleagues at Osaka University in Osaka and Tokai University in Kanagawa.

IL-6 activates and enhances HHV-8 and HIV replication, Song and coauthors found.

The researchers used a BCBL tumor cell line to examine the effect of IL-6 on HHV-8 activity. Exposing these cells...

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