Immunology

Chronic T cell activation induces immunodeficiency

Published in AIDS Weekly, December 30th, 2002

One of the hallmarks of infection with HIV is a reduction in the number of CD4 T cells to dangerously low levels. How this depletion occurs, whether by direct killing of the CD4 T cells or chronic activation of the immune system, was not understood.

In the January 2002 issue of Nature Immunology, scientists showed that persistent immune activation, even with no viral infection, can, indeed, lead to immunodeficiency.

Van Lier and colleagues, from the Academic Medical Center in Amsterdam, the Netherlands, generated mice in which T cells are constantly activated - which mimics the immune system during a persistent infection with HIV. Chronic...

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Source: AIDS Weekly (2002-12-30)

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