HIV/AIDS Therapy

Angiostatin prevents Tat-induced vasculopathy

Published in AIDS Weekly, January 6th, 2003

by Michael Greer, senior medical writer - The antiangiogenic peptide angiostatin can prevent vascular damage triggered by HIV proteins, researchers in Italy report.

"The HIV-Tat protein can be released extracellularly where it is able to recruit leukocytes and induce angiogenesis," explained Roberto Benelli and colleagues at National Institute for Cancer Research in Genoa.

Angiostatin blocks the inflammatory angiogenic response to extracellular Tat, Benelli and coauthors found.

The researchers evaluated the performance of angiostatin in vitro using chemotaxis assays. The peptide significantly suppressed Tat-induced neutrophil...

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Source: AIDS Weekly (2003-01-06)

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