Immunology

Chronic T cell activation induces immunodeficiency

Published in AIDS Weekly, January 27th, 2003

One of the hallmarks of infection with HIV is a reduction in the number of CD4 T cells to dangerously low levels. How this depletion occurs, whether by direct killing of the CD4 T cells or chronic activation of the immune system, was not understood. Now scientists show that persistent immune activation, even with no viral infection, can indeed lead to immunodeficiency.

Van Lier and colleagues, from the Academic Medical Center in Amsterdam, generated mice in which T cells are constantly activated - which mimics the immune system during a persistent infection with HIV. Chronic activation of the immune system induced a progressive depletion of T cells that was...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of AIDS Weekly

Source: AIDS Weekly (2003-01-27)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry