HIV/AIDS Pathogenesis
Cell surface CCR5 density determines postentry efficiency of R5 HIV infection
Published in AIDS Weekly, February 3rd, 2003
"We have recently reported that the mean number of CCR5 coreceptors at the surface of CD4+ T cells (CCR5 density) correlates with viral load and disease progression in HIV-1-infected persons," stated Y. L. Lin and colleagues, Institute de Genetique Humaine. "Here, we definitively establish that CCR5 density determines the level of virus production and identify the stages of HIV-1 replicative cycle modulated by this effect."
"We sorted HOS-CD4+-CCR5+ cells into two subpopulations, HODhigh and HOSlow, the former...
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Source: AIDS Weekly (2003-02-03)
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