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HIV/AIDS Therapy

Naive CD4 cells act as viral resevoirs in antiretrioviral-treated patients

Published in AIDS Weekly, February 10th, 2003

In a recent report, researchers in France conducted a study "to investigate the phenotypic features of infected lymphocytes in patients on prolonged and effective highly active antiretroviral therapy (HAART)."

"We examined highly purified subsets of memory and naive CD4 T lymphocytes for the presence of replication-competent virus," acording to O. Lambotte and coauthors, Kremlin Bicetre Hospital.

The researchers "isolated highly purified CD45RO+CD45RA+CD4+ T cells using a magnetic bead-based procedure" from 11 patients succesfully treated with HAART. "In some patients, a subsequent cell separation according to CD62L expression was performed." We...

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