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AIDS Weekly

Susan Hasty, Publisher

Table of Contents . . . February 17th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in AIDS Weekly | Other Publications

HIV/AIDS Vaccine -  Salmonella-based priming improves mucosal antiviral response

HIV/AIDS Vaccine - Effects of viral protein modifications on immunogenecity characterized

AIDS/HIV Therapy -  Terminalia triflora extract inhibits reverse transcriptase activity

HIV/AIDS Genetics and Genomics - Novel recombinant strains found in China

HIV/AIDS Pathogenesis - Viral Vpr protein upregulates Survivin

HIV/AIDS Proteomics - CD4 binding site antibodies block gp120-CCR5 interaction

AIDS Prevention - Annan welcomes Bush's $15 billion pledge for global fight against HIV/AIDS

AIDS Prevention - Bush plan, defying some political supporters, includes condoms and generic drugs

AIDS Prevention - Researchers take antibody production from cell culture to plants to stop HIV

AIDS Prevention - Treatment to prevent mother-to-child HIV transmission in Mozambique

AIDS Prevention - Vietnam develops nation's first long-term strategy to combat HIV

AIDS Therapy - Chinese company distributes anti-AIDS "cocktail"

AIDS Therapy - VaxGen hopes AIDS vaccine trial results warrant FDA filing but skeptics abound

Antiangiogenesis - Angiostatin inhibits extracellular HIV-Tat-induced inflammatory angiogenesis

Awards - Two Emory scientists receive biotech growth award for drug research

Cachexia - Oxandrolone, exercise, nutrition boost weight and lean tissue gain in patients

Cancer Research - Feline immunodeficiency virus integration in B-cell lymphoma reveals tumor suppressor gene

Funding - Organization praises U.S. Senate action on global AIDS fight

Global Health - Pilot program launched to expand access to medicines in poorest countries

HIV-1 Integrase - MSH derivatives may serve as leads for antiviral therapeutics

HIV/AIDS Animal Models - HIV-2 virulence increases after serial passage in baboons

HIV/AIDS Epidemiology - HIV-1 group M subtypes infecting persons in Cameroon countryside

HIV/AIDS Genetics and Genomics - DC-SIGN gene family variations seen between human and nonhuman primates

HIV/AIDS Genetics and Genomics - Sequences downstream of 5 ' splice donor site needed for RNA dimerization

HIV/AIDS Opportunistic Infection - Prophylaxis against several pathogens remains cost-effective

HIV/AIDS Pathogenesis - Antibodies can enhance antigen cross presentation

HIV/AIDS Pathogenesis - Disulfide-linked integrase oligomers not needed for viral replication

HIV/AIDS Pathogenesis - N-linked glycan g15 in gp120 V3 loop blocks neutralizing antibodies

HIV/AIDS Pathogenesis - Viral Nef downregulates MHC-I by a PACS-1-and PI3K-regulated ARF6 endocytic pathway

HIV/AIDS Pathogenesis - Virus-specific cytotoxic T cells characterized

HIV/AIDS Proteomics - Artificial SH3 domains tightly bind SIV Nef

HIV/AIDS Proteomics - Differential acetylation of Tat coordinates cyclin T1 and PCAF interactions

HIV/AIDS Proteomics - Membrane-binding domain region involved in retroviral budding identified

HIV/AIDS Proteomics - Protease dimer interactions influence activation and GagPol cleavage specificity

HIV/AIDS Research - Viral Tat targets microtubules to induce CD4 cell apoptosis

HIV/AIDS Therapy - Depression is risk factor for suboptimal therapy adherence

HIV/AIDS Therapy - Enfuvirtide safe and effective against drug-resistant infection

HIV/AIDS Therapy - Feedback loop seen between HAART adherence and adipose tissue alterations

HIV/AIDS Therapy - Lentivirus vectors effective for gene therapy, but carry risks

HIV/AIDS Therapy - Nelfinavir exposure enhances replication of novel viral strain

HIV/AIDS Therapy - Novel agents inhibit viral Vpr protein function

HIV/AIDS Treatment - HAART-persistent HIV-1 latent reservoirs may be eliminated by immune activation

HIV/AIDS Treatment - Indinavir/ritonavir provided viral suppression in PI-naive patients

HIV/AIDS Treatment - SIV infection model for assessing the role of selenium in AIDS

Healthcare Access - Progress reported in cutting AIDS drug prices for poor nations

Herpesvirus Infection - Cidofovir fails to treat Kaposi sarcoma in a pilot study

Immune Cell Distribution - HIV-1 plasma viremia is shown to influence dendritic cell number and activity

Oral Surgery - HIV infection does not affect hemophiliac's complication risk

Policy - Central America, drug companies reach agreement to lower cost of AIDS drugs

Thrombotic Microangiopathy - Prolonged lowering of CD4(+) T cells may be cause; risk lowered after HAART

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