HIV/AIDS Pathogenesis

Cellular gene expression upon CD4 cell infection characterized

Published in AIDS Weekly, February 24th, 2003

Researchers at the University of Washington have elucidated the changes in T-cell gene expression following HIV infection.

"The expression levels of similar to 4,600 cellular RNA transcripts were assessed in CD4+ T-cell lines at different times after infection with human immunodeficiency virus type 1 strain BRU (HIV-1(BRU)) using DNA microarrays," wrote A. B. van 't Wout and colleagues, who "found that several classes of genes were inhibited by HIV-1(BRU) infection, consistent with the G₂ arrest of HIV-1-infected cells induced by Vpr."

"These included genes involved in cell division and transcription, a family of DEAD-box proteins (RNA...

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Source: AIDS Weekly (2003-02-24)

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