HIV/AIDS Dementia

Ethanol strongly potentiates virus-induced apoptosis in brain microvascular cells

Published in AIDS Weekly, February 24th, 2003

"Ethanol may have significant effects on human immunodeficiency virus type I (HIV-1) pathogenesis in vivo," according to a recent study from the United States.

E. Acheampong and colleagues at Thomas Jefferson University investigated "the proapoptotic potential of various HIV-1 proteins in primary isolated human brain microvascular endothelial cells (MVECs), a major cellular component of the blood-brain barrier."

"Low-passage primary brain MVEC were treated with recombinant HIV-1 proteins Nef, Vpr, Tat and gp120 proteins from X4, R5, and X4R5 viral strains, with and without ethanol at various relevant concentrations," they said. "The apoptotic...

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Source: AIDS Weekly (2003-02-24)

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