HIV/AIDS Pediatric

Molecular and cellular TCR Vbeta repertoire tests yield discrepant results

Published in AIDS Weekly, March 10th, 2003

Molecular and cellular techniques for analyzing T-cell receptor (TCR) Vbeta repertoir yield discrepant results in pediatric HIV patients.

In a recent study from New York University, TCR Vbeta diversity was "assessed in the CD4 and CD8 T lymphocytes of human immunodeficiency virus (HIV)-infected children who were receiving therapy during the chronic phase of infection by flow cytometry (FC) and PCR analysis."

"By FC, representation of 21 TCR Vbeta subfamilies was assessed for an increased or decreased percentage in CD4 and CD8 T cells, and by PCR, 22 TCR Vbeta subfamilies of CD4 and CD8 T cells were analyzed by CDR3 spectratyping for perturbations and...

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Source: AIDS Weekly (2003-03-10)

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