HIV/AIDS Vaccine

RANTES, CpG ODNs effective as mucosal adjuvants

Published in AIDS Weekly, March 17th, 2003

by Michael Greer, senior medical writer - Researchers at Emory University in Atlanta have identified a pair of adjuvants that can be used to enhance the effects of mucosal HIV vaccines.

"Cholera toxin (CT) is the most potent known mucosal adjuvant, but its toxicity precludes its use in humans," explained Sang-Moo Kang and colleagues.

The chemokine RANTES and CpG oligodeoxynucleotides (ODN) strongly improved vaccine-induced humoral activity in a simian model, and were much less toxic than CT, Kang and coauthors found.

The researchers immunized nonhuman primates with a nasal simian immunodeficiency virus (SIV) vaccine and either CT,...

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Source: AIDS Weekly (2003-03-17)

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