HIV/AIDS Therapy
Inhibitory quotient predicts virological response
Published in AIDS Weekly, March 24th, 2003
"Increased drug levels could overcome resistance and improve the response to a salvage regimen," argued researchers in Spain.
J. L. Casado and colleagues at Hospital Ramon y Caja evaluated "the inhibitory quotient (IQ, C-trough/protein-binding corrected IC50) as a predictor of virological response in 52 patients included in two dual protease inhibitor (PI)-based salvage regimens."
"The HIV-RNA level decrease at 12 weeks was greater in patients who achieved an IQ greater than 1," their report indicated.
The...
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Source: AIDS Weekly (2003-03-24)
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