Diagnostics

Novel molecular conjugates aid signal amplification for immunodiagnostic assays

Published in AIDS Weekly, March 31st, 2003

The conjugation of multiple horseradish peroxidase molecules to immunoglobulin via primary amines on lysine peptide chains provided novel molecular conjugates for signal amplification.

According to a study from the United States, "Immunoconjugates are widely used for indirect detection of analytes (such as antibodies or antigens) in a variety of immunoassays. However, the availability of functional groups such as primary amines or free sulfhydryls in an immunoglobulin molecule is the limiting factor for optimal conjugation and, therefore, determines the sensitivity of an assay. In the present study, an N-terminal bromoacetylated 20 amino acid peptide containing 20...

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Source: AIDS Weekly (2003-03-31)

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