Kaposi Sarcoma

Viral gene responsible for oncogenesis identified

Published in AIDS Weekly, March 31st, 2003

The guilty gene responsible for initiating oncogenesis in Kaposi sarcoma has been identified - at last - by researchers at Weill Cornell Medical College.

Kaposi sarcoma associated herpes virus (KSHV), which is consistently detected within this highly vascularized cancer, carries the gene, vGPCR. The vGPCR (viral G-protein coupled receptor) gene has been a suspect for a long time. However, scientists have been faced with the conundrum that vGPCR is not expressed either long enough or in enough of the cells within the KS tumor to be "pinned" down.

Now, Dr. Enrique Mesri of Weill Cornell and colleagues propose a new scenario and a new mechanism -...

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Source: AIDS Weekly (2003-03-31)

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