HIV/AIDS Lipodystrophy

Leptin may play role in abnormal fat distribution

Published in AIDS Weekly, April 14th, 2003

by Michael Greer, senior medical writer - Researchers in the United States say that leptin, an appetite-suppressing hormone produced by fat cells, may be involved in the development of HIV-related lipodystrophy.

G. Sonia Nagy and colleagues working at Harvard Medical School's Beth Israel Deaconess Medical Center in Boston investigated the "relationship between the adipocyte-derived hormone leptin, insulin resistance, and fat redistribution" in HIV patients.

Serum leptin levels were significantly altered in patients with abnormal fat distribution after antiretroviral therapy, Nagy and coauthors found.

The researchers examined 120...

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Source: AIDS Weekly (2003-04-14)

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