Published in AIDS Weekly, April 21st, 2003
HIV Tat "is essential for virus replication and is a candidate vaccine antigen," explained Ilia Tikhonov and colleagues at the University of Maryland Biotechnology Institute. "Macaques immunized with Tat or chemically modified Tat toxoid having the same clade B sequence developed strong antibody responses."
Both of these vaccine strategies produced Tat-specific neutralizing antibodies in treated animals, although the breadth of antisera cross-reactivity was...
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