HIV/AIDS Pathogenesis

"Glycan shield" may prevent antibody neutralization

Published in AIDS Weekly, April 28th, 2003

A "glycan shield" may prevent antibody neutralization of HIV during acute infection.

"Neutralizing antibodies (Nab) are a principal component of an effective human immune response to many pathogens, yet their role in HIV-1 infection is unclear," researchers in the United States explained.

"To gain a better understanding of this role," X.P. Wei and colleagues at the University of Alabama "examined plasma from patients with acute HIV infection."

This examination revealed "autologous Nab as early as 52 days after detection of HIV-specific antibodies," Wei and coworkers reported. "The viral inhibitory activity of Nab resulted in...

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Source: AIDS Weekly (2003-04-28)

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