HIV/AIDS Pathogenesis

C4 gp120 residues do not play key role in CCR5 interaction

Published in AIDS Weekly, April 28th, 2003

The C4 region of the HIV coat protein gp120 does not play a key role in gp120-CCR5 interactions.

According to recent research from the United States, "the V3 loop and the bridging sheet domain of human immunodeficiency virus type 1 (HIV-1) subtype B envelope glycoprotein gp120 have been implicated in CCR5 coreceptor utilization."

P. Suphaphiphat and coauthors at Harvard University conducted a study in which "mutant envelope glycoproteins of a subtype C isolate containing substitutions in the V3 or C4 region were generated to determine which are required for efficient CCR5-dependent cell fusion and viral entry."

The results showed...

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Source: AIDS Weekly (2003-04-28)

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