HIV/AIDS Therapy

Anti-Vpu antibodies are sign of effective treatment

Published in AIDS Weekly, April 28th, 2003

The emergence of antibodies targeting the HIV Vpu protein is a sign of effective antiretroviral treatment.

HIV Vpu "promotes both extracellular release of viral particles and degradation of CD4 in the endoplasmic reticulum," researchers in Taiwan noted.

"The correlation of anti-Vpu antibody (Ab) reactivity to Vpu and AIDS disease progression was studied in 162 HIV-1/AIDS patients after they had received highly active antiretroviral therapy (HAART) for one year," according to Y.M.A. Chen and coauthors at National Yang-Ming University. "Anti-Vpu Ab reactivity was analyzed by Western blot using a recombinant Vpu protein."

"Results...

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Source: AIDS Weekly (2003-04-28)

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