HIV/AIDS Therapy

Trichosanthin ribosome suppression not linked to antiretroviral effects

Published in AIDS Weekly, April 28th, 2003

The antiretroviral effects of trichosanthin (TCS) are not linked to its effects on ribosomes.

TCS "is a type I ribosome-inactivating (RI) protein possessing multiple biological and pharmacological activities," researchers in China explained. "Its major action is inhibition of human immunodeficiency virus (HIV) replication but the mechanism is still elusive."

"Previous studies found that TCS mutants with reduced RI activity simultaneously lost some anti-HIV activity," noted J.H. Wang and coauthors at the Chinese Academy of Sciences.

However, "an exception was demonstrated by two TCS mutants retaining almost all RI activity but were...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of AIDS Weekly

Source: AIDS Weekly (2003-04-28)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry