HIV/AIDS Therapy

U6 cassette enables high-level expression of antiviral small RNAs

Published in AIDS Weekly, April 28th, 2003

A U6 RNA cassette enables high-level expression of HIV-inhibiting small RNAs.

According to recent research from the United States, "several types of small RNAs have been proposed as gene expression repressors with great potential for use in gene therapy."

"RNA polymerase III (pol III) provides an ideal means of expressing small RNAs in cells because its normal products are small, highly structured RNAs that are found in a variety of subcellular compartments," explained C.P. Paul and coauthors at the University of Michigan.

Paul and coworkers "designed cassettes that use human pol III promoters for the high-level expression of...

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Source: AIDS Weekly (2003-04-28)

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