HIV/AIDS Transmission

Oral epithelial cells can contribute to infection

Published in AIDS Weekly, April 28th, 2003

Oral epithelial cells can contribute to HIV transmission.

"Recent epidemiologic studies show increasing human immunodeficiency virus type 1 (HIV-1) transmission through oral-genital contact," investigators in California noted.

With this in mind, X.A. Liu and colleagues at the Charles R. Drew University of Medicine and Science examined "the possibility that normal human oral keratinocytes (NHOKs) might be directly infected by HIV or might convey infectious HIV virions to adjacent leukocytes."

"PCR analysis of proviral DNA constructs showed that NHOKs can be infected by CXCR4-tropic (NL4-3 and ELI) and dual-tropic (89.6) strains of...

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Source: AIDS Weekly (2003-04-28)

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