HIV/AIDS Proteomics
Six-helix bundle may protect fusion pores
Published in AIDS Weekly, May 5th, 2003
"Fusion proteins of many viruses, including HIV-1 envelope protein (Env), fold into six-helix bundle structures," researchers in the United States explained.
In a recent study conducted by R.M. Markosyan and colleagues at Rush Medical College, "fusion between individual Env-expressing cells and target cells was studied by fluorescence microscopy, and a temperature jump technique, to determine whether folding of Env into a bundle is complete by the time fusion pores have formed."
"Lowering temperature to 4 degrees C immediately after a pore opened halted pore...
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Source: AIDS Weekly (2003-05-05)
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