HIV/AIDS Vaccine

Peptide constraints enhance anti-gp41 immunogenicity

Published in AIDS Weekly, May 5th, 2003

by Michael Greer, senior medical writer - Researchers in the United States have found a way to improve the efficacy of an anti-HIV monoclonal antibody that could serve as the basis for an effective vaccine.

The HIV "transmembrane glycoprotein gp41 mediates viral entry through fusion of the target cellular and viral membranes," explained G.B. McGaughey and colleagues at Merck Research Laboratories in West Point, Pennsylvania. "A segment of gp41 containing the sequence Glu-Leu-Asp-Lys-Trp-Ala has previously been identified as the epitope of the HIV-1 neutralizing human monoclonal antibody 2F5 (MAb 2F5)."

McGaughey and coauthors identified an amino acid...

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Source: AIDS Weekly (2003-05-05)

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