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HIV/AIDS Vaccine

Adenovirus vector shows promise

Published in AIDS Weekly, May 5th, 2003

by Michael Greer, senior medical writer - A novel vector shows promise for use in HIV and other vaccines, researchers in Maryland say.

"A strategy to circumvent immune responses to adenovirus (Ad) resulting from natural infection or repeated vector administrations involves sequential use of vectors from different Ad serotypes," explained X. Nan and colleagues at the National Cancer Institute in Bethesda and Gaithersburg-based GenVec, Inc.

A series of recombinant Ad vectors efficiently expressed key HIV proteins, and could be modified to carry other genes of interest, Nan and coauthors said.

The researchers developed a...

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