HIV/AIDS Vaccine

Human immunodeficiency virus may use transcytosis to cross genital mucosa

Published in AIDS Weekly, May 12th, 2003

The human immunodeficiency virus may use transcytosis across a tight monolayer of polarized human endometrial cells under pro-inflammatory conditions.

According to recent research from France, "Most cases of human immunodeficiency virus (HIV) infection worldwide occur following sexual contact, implying that the virus may breach the protective epithelial barrier lining the genital tract. HIV infection is known to preferentially occur when the genital epithelial integrity is altered, particularly when epithelial micro-ulcerations occur during heterosexual intercourse or ulcerations appear, due to sexually transmitted infections or else in the context of ectopy of the...

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Source: AIDS Weekly (2003-05-12)

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