HIV Immunology

Intact CD4+ T-lymphocyte cytokine expression capacity linked to stable clinical status

Published in AIDS Weekly, May 26th, 2003

Study findings reported by Beth Israel Deaconess Medical Center, Harvard Medical School, researchers suggest that intact CD4+ T-lymphocyte cytokine expression capacity is associated with stable clinical status in AIDS patients.

"Human immunodeficiency virus type 1 infection results in a dysfunction of CD4+ T lymphocytes. The intracellular events contributing to that CD4+ T-lymphocyte dysfunction remain incompletely elucidated, and it is unclear whether aspects of that dysfunction can be prevented," wrote P.F. McKay and colleagues.

Their study incorporates a rhesus monkey model of AIDS.

"Loss of the capacity of peripheral blood...

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Source: AIDS Weekly (2003-05-26)

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