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Vaccine Development

T-helper cell response to HIV envelope protein is limited

Published in AIDS Weekly, May 26th, 2003

Single-envelope vaccines can often fail to provoke an immune response sufficiently diverse to recognize variant sequences among circulating HIV, authors of a Journal of Virology study concluded.

"Single-envelope human immunodeficiency virus (HIV) vaccines have been studied for more than a decade, with some successes in homologous challenge experiments in nonhuman primates but with no clear successes in clinical trials," said X. Zhan and colleagues. "To gain insight into the breadth of the immunity elicited by such vaccines, we have dissected the T-helper cell response of C57BL/6 mice to an individual, molecularly cloned envelope protein."

The...

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