HIV/AIDS Pathogenesis

YY1 transcription factor lowers CCR5 expression

Published in AIDS Weekly, June 2nd, 2003

The YY1 transcription factor reduces cellular levels of the HIV coreceptor CCR5.

Expression of this molecule "is regulated by a number of transcription factors," scientists in Japan explained.

In a recent study, H. Moriuchi and colleagues at Nagasaki University Hospital found that "the YY1 transcription factor downregulates CCR5 promoter activity".

Moreover, "overexpression of YY1 reduces cell surface CCR5 expression and infectibility by R5-HIV-1," according to the report.

"Because YY1 also downregulates promoter activities of CXCR4, another major coreceptor for HIV-1 and the HIV-1 long terminal repeat, this...

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Source: AIDS Weekly (2003-06-02)

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