Published in AIDS Weekly, June 2nd, 2003
In a recent study, H. Moriuchi and colleagues at Nagasaki University Hospital found that "the YY1 transcription factor downregulates CCR5 promoter activity".
Moreover, "overexpression of YY1 reduces cell surface CCR5 expression and infectibility by R5-HIV-1," according to the report.
"Because YY1 also downregulates promoter activities of CXCR4, another major coreceptor for HIV-1 and the HIV-1 long terminal repeat, this...
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