Pediatric HIV/AIDS

Virus-specific CD8 cell function often impaired in young children

Published in AIDS Weekly, June 2nd, 2003

HIV-specific cytotoxic T-cell function is often impaired in young seropositive children with low CD4 cell counts.

"The immunology of vertical HIV transmission differs from that of adult infection in that the immune system of the infant is not fully matured, and the factors that influence the functionality of CD8+ T-cell responses against HIV in children remain largely undefined," researchers in Sweden noted.

To determine these factors, J.K. Sandberg and coauthors "investigated CD8+ T cell responses in 65 pediatric subjects with vertically acquired HIV-1 infection."

"Vigorous, broad, and Ag [antigen] dose-driven CD8+ T-cell...

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Source: AIDS Weekly (2003-06-02)

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