Virology

Protective gene mutation found in some HIV patients

Published in AIDS Weekly, June 9th, 2003

Mayo Clinic researchers have identified a naturally occurring "good guy" for patients infected with HIV. It is a helpful gene mutation that impairs the HIV virus' cell-killing machinery, thus preserving immune system function.

Moreover, Mayo's experiments in mice suggest that the presence or absence of this mutation in the gene known as Vpr may play a central role in determining which HIV-infected patients develop full-blown, fatal AIDS.

If these findings hold up, this "good guy" mutation could lead to new AIDS therapies based upon Vpr inhibitors to reduce immune-system cell death during HIV infection. By preserving these immune system cells - known...

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Source: AIDS Weekly (2003-06-09)

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