HIV/AIDS Immunology

Low plasma nerve growth factor levels linked to B-cell loss

Published in AIDS Weekly, June 9th, 2003

Low plasma levels of nerve growth factor (NGF) may underlie memory B-cell loss during HIV infection.

NGF "regulates B-cell activation and differentiation and is an autocrine survival factor for memory B lymphocytes," researchers in Sweden explained.

K. Titanji and colleagues at the Karolinska Institute, who "reported recently that the number of memory B cells is reduced during HIV-1 infection," conducted a study to determine "whether alteration in the NGF supply was involved in memory B cell loss in HIV-1-infected subjects."

A "high rate of cell death in vitro was observed in memory B cells from HIV-1-infected individuals compared...

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Source: AIDS Weekly (2003-06-09)

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