Published in AIDS Weekly, June 9th, 2003
According to a recent study from France, "the structure of new lipopeptides targeting the enzymic dimer interface have been rationally improved, resulting in dimerization inhibitors of the human immunodeficiency virus 1 protease (K-id = 5 nM for the best inhibitor)."
"The contribution of each amino acid in inhibitory 3-mer lipopeptides was analyzed, demonstrating that the C-terminal amino acid residue may preferably be replaced by thyroxine and thyronine," according to J. Dumond and coauthors at the University of Paris.
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