HIV/AIDS Proteomics

Promyelocytic leukemia protein aids Tat activity through cyclin T1 recruitment

Published in AIDS Weekly, June 23rd, 2003

The promyelocytic leukemia protein aids HIV Tat activity through cyclin T1 recruitment.

"Human cyclin T1, the cyclin partner of Cdk9 kinase in the positive transcription elongation factor b (P-TEFb), is an essential cellular cofactor that is recruited by the human immunodeficiency virus type 1 (HIV-1) Tat transactivator to promote transcriptional elongation from the HIV-1 long terminal repeat (LTR)," scientists in Italy explained.

In their study, A. Marcello and colleagues at the International Center for Genetic Engineering and Biotechnology in Trieste used "fluorescence resonance energy transfer (FRET) to demonstrate that cyclin T1 physically...

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Source: AIDS Weekly (2003-06-23)

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