HIV/AIDS Dementia
Sindbis virus expression vectors aid research
Published in AIDS Weekly, June 30th, 2003
SIN expression vectors "offer the opportunity for studying neuropathogenesis because of their distinct neural cell tropism," scientists in Canada explained.
In their study, G. van Marle and coauthors at the University of Calgary demonstrated that "a recombinant SIN vector expressing EGFP (SINrep5-EGFP) infected multiple cell types including neural cells from several species relevant to lentivirus pathogenesis with high levels of transgene expression."
"Infection of human neurons by a recombinant SIN (SINrep5-JRFL) expressing the full-length...
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Source: AIDS Weekly (2003-06-30)
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