Kaposi Sarcoma

Novel cell line enables high-level production of KSHV DNA polymerase

Published in AIDS Weekly, July 7th, 2003

A novel cell line enables high-level production of a key DNA enzyme involved in Kaposi's sarcoma pathogenesis.

"The DNA polymerase (POL) of Kaposi's sarcoma-associated herpesvirus (KSHV) is essential for viral DNA replication and, thus, may be considered as a viable target for anti-KSHV therapeutics," researchers in the United States explained.

"To produce large quantities of homogeneous and pure POL required for high-throughput screening (HTS) for inhibitors," D. Dorjsuren and colleagues working at Science Applications International Corporation (SAIC)-Frederick in Ft. Detrick, Maryland "generated a recombinant baculovirus vector encoding a...

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Source: AIDS Weekly (2003-07-07)

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